The NFL world was at a loss for words after San Francisco 49ers star Christian McCaffrey fell victim to another serious injury in Sunday’s 35-10 loss to the Buffalo Bills. McCaffrey appeared to suffer a non-contact knee injury in the second quarter and was quickly ruled out for the rest of the game.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A knee injury knocked the running back out of Sunday night's Week 13 matchup with the Buffalo Bills,

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey suffered a PCL injury in his right knee in what is feared to be season-ending, according to 49ers head coach Kyle Shanahan.

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ligament in his knee.

Get the latest update on Christian McCaffrey's injury: a potentially season-ending PCL injury that happened Week 13.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

San Francisco 49ers star running back Christian McCaffrey's season is in jeopardy after he sustained what is believed to be a posterior cruciate ligament injury in Sunday's 35-10 loss to the Buffalo Bills in Orchard Park,

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s playoff hopes now hang in

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for catching his own touchdown pass in a Buffalo Bills thrashing of the San Francisco 49ers.