With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and San Francisco 49ers.

We're live with the Week 13 edition of "Sunday Night Football" as the Buffalo Bills play host to the San Francisco 49ers to cap what has been a wild Thanksgiving weekend of NFL games. San Francisco enters this game incredibly banged up,

Buffalo Bills running back James Cook looked phenomenal in his team's Week 13 win over the San Francisco 49ers, and his brother wants him to be compensated.

NFL Week 13 closes with Sunday Night Football as the San Francisco 49ers visit Highmark Stadium and the Buffalo Bills. Time and how to watch.

A pair of Super Bowl hopefuls from each conference meet up on Sunday, Dec. 1 to close out the NFL schedule for the day with the Buffalo Bills hosting the San Francisco 49ers at Highmark Stadium in Orchard Park, NY.

Buffalo Bills quarterback Josh Allen had fun in the snow as his team produced an offensive avalanche to blow away the San Francisco 49ers 35-10 in the NFL on Sunday. Allen followed up that score with a 7-yard pass to Mack Hollins,

SportsLine's model has simulated San Francisco vs. Buffalo on Sunday Night Football 10,000 times and revealed its SNF picks and NFL predictions

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's Adam Schefter. Purdy was

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?