San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle ...

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey ...

The NFL world was at a loss for words after San Francisco 49ers star Christian McCaffrey fell victim to another serious ...

San Francisco 49ers star Christian McCaffrey is believed to have suffered a PCL injury during the Niners’ 35-10 loss to the ...

The 49ers’ goal last offseason was to strengthen their depth in pursuit of another NFC crown. That depth has been tested and ...

It doesn't seem like this is going to be the 49ers' year to get over the hump, but that doesn't mean that big changes are ...

The Los Angeles Rams' bitter rival suffered yet another devastating injury during their Week 13 road loss against the Buffalo ...

Replacing McCaffrey won't be easy for fantasy football managers, but these three running backs present the most viable ...

Matthew Berry, Jay Croucher and Connor Rogers dive into the ramifications of star Christian McCaffrey's latest injury, ...

Highlighting the players fantasy managers should consider adding off the waiver wire for Week 14, including replacement ...

The San Francisco 49ers dropped their record to 5-7 after a 35-10 loss against the Buffalo Bills in Week 13. Today, Pro ...

Catch up on the latest San Francisco 49ers headlines, powered by..... 49ers Notebook: Reflecting on playing in snowy weather; ...