The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on the season. With their playoff hopes dwindling, questions are mounting ...

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back ...

One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

The NFL world was at a loss for words after San Francisco 49ers star Christian McCaffrey fell victim to another serious ...

The Los Angeles Rams' bitter rival suffered yet another devastating injury during their Week 13 road loss against the Buffalo ...

San Francisco 49ers star Christian McCaffrey is believed to have suffered a PCL injury during the Niners’ 35-10 loss to the ...

The 49ers’ goal last offseason was to strengthen their depth in pursuit of another NFC crown. That depth has been tested and ...

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey ...

The New York Jets plan to keep Aaron Rodgers as the starting quarterback, despite his struggles and 3-9 record this season, ...

Replacing McCaffrey won't be easy for fantasy football managers, but these three running backs present the most viable ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...