Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

San Francisco 49ers edge rusher Leonard Floyd is excited to face his former Buffalo Bills and ex-teammate Josh Allen in Week ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

Star receiver George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

Here’s how you can watch, stream and listen to the game. Bills vs. 49ers will air on NBC. Mike Tirico will be on play-by-play ...

This Sean McDermott stat should give Buffalo Bills fans confidence entering their Week 13 matchup with the San Francisco ...

The San Francisco 49ers are playing Brandon Allen at quarterback in Week 12 against the Green Bay Packers. The team’s ...

San Francisco 49ers head coach Kyle Shanahan told reporters that quarterback Brock Purdy did some light throwing without any ...

Two words can sum up the Week 12 matchup between the visiting San Francisco 49ers and the host Green Bay Packers: utter ...