The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

The San Francisco 49ers have struggled to get Deebo Samuel going, and one NFL analyst thinks they may not be able to.

When Kyle Shanahan became head coach of the San Francisco 49ers in 2017, the team was in the midst of a rebuilding phase.

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

See who's in and who's out for the Week 14 matchup between the San Francisco 49ers and Chicago Bears on December 8, 2024.

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

Josh Allen and the Buffalo Bills put on a show in the snow during "Sunday Night Football" in Week 13, besting the San ...