For as disjointed and dry as the 49ers are offensively, it's their run defense that has crushed their chances and led to road ...

The San Francisco 49ers entered Sunday night's matchup against the Buffalo Bills at Highmark Stadium without several key ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

Quarterback Brock Purdy did not waste any time in getting the ball into the hands of 49ers tight end George Kittle on Sunday.

The San Francisco 49ers entered Sunday's game at Lambeau Field against the Green Bay Packers at a clear disadvantage. They ...

After Sunday night's humbling loss in snowy Buffalo, it's time for Kyle Shanahan and John Lynch to start shutting ...

These are the cold, hard facts. The 49ers received another snowball upside their heads — figuratively and, perhaps, literally ...

The 49ers' run game was going well until it wasn't in their 35-10 loss to the Buffalo Bills on Sunday at Highmark Stadium.

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...