The Buffalo Bills dismantled the San Francisco 49ers 35-10 at Highmark Stadium, and clinched the AFC East in the process.

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.

The Houston Texans will head into their off week breathing a sigh of relief. After losing four of the previous six games, the ...

The San Francisco 49ers looked out of their element as the Buffalo Bills cruised to an easy 35-10 win on Sunday Night ...

The Lake-effect snowstorm that severely affected parts of Buffalo, New York, Pennsylvania, and Michigan this Thanksgiving ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday Night Football, rumbling past them 35-10. Not only did this win ...

Bills quarterback Josh Allen and head coach Sean McDermott celebrated by making snow angels after Buffalo clinched its fifth consecutive AFC East title in an epic snow game against the 49ers.

In an otherwise boring game against San Francisco -- the result of the game was never in question -- Bills quarterback Josh ...

Well, that wasn't fun. The San Francisco 49ers looked like they were cooking early in the game, but eventually, the Buffalo ...

The Detroit Lions offensive coordinator is at the top of most fan's wishlists. Here are two reasons the Bears should hire him ...

A close game in New York ended with the Seahawks pulling ahead in the fourth quarter, securing the win. Let's rewind. Today's ...