While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

Star receiver George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

The Bills will take on the San Francisco 49ers on Sunday night at Highmark Stadium in Orchard Park. Lake-effect snow bands ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

Buffalo (9-2) will return to action on Sunday night when they host the San Francisco 49ers (5-6). The Bills are perfect ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have ...