San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The Buffalo Bills didn't just beat the San Francisco 49ers on Sunday night. They destroyed the reigning NFC champions. The ...

Christian McCaffrey was having a resurgent game against the Buffalo Bills. He finally looked like the player who was supposed ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Buffalo Bills quarterback Josh Allen had fun in the snow as his team produced an offensive avalanche to blow away the San ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

The Bills controlled the game on the ground as the snow played a significant role, with Buffalo finishing the game with 220 ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.